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Cedars-Sinai Biostatistics –Fall Quarter - Presentations, Assignments and other material

        Instructor:  Jeff Gornbein DrPH   gornbein@g.ucla.edu     

     Home phone:  310-392-7381    office: 310-825-4193

 

  Class topics schedule & texts (updated)    Handy EXCEL functions      Gaussian (normal) table

     Suggested texts:  Petrie and Sabin (P&S)   Medical Statistics at a Glance 4th ed, Wiley-Blackwell Pub 2020,   Motulsky H, Intuitive Biostatistics, 4th ed, Oxford Univ Press 2018

 

 Link to class Zoom session:  https://uclahs.zoom.us/j/3680482651

     Meeting ID: 368 048 2651

 

        Class presentation slides by topic- will be updated  

  1. Study design

  2. Descriptive stats-survival & binary data, Sensitivity, Specificity and ROC

  3. Probability theory & distributions: Normal, binomial, Poisson – Bayes rule

  4. Confidence intervals & hypothesis testing, p values

        Paper on the misinterpretation of p values (Lytsy-2022)

  5. Sample size for precision & power, multiple hypothesis testing

  6. Analysis of variance (ANOVA)

  7. Chi square and F tests – overall tests

 8a. Simple Linear Regression

 8b. Multiple regression – brief intro to linear, logistic, Poisson & Cox regression

  9.  Logistic regression

 9B.  Tree models

 9C.  Propensity scores & logistic regression

 10. Survival and Cox regression

 11. Factor analysis

 12.  Stat reporting tips for stats in publications  

 

       Class notes (backup, less up to date):

 

 

   Semi serious stat survey – a screening test (not for a grade-do not need to hand in)

 

  Assignments: Due dates will be extended if material has not yet been covered

             Send assignment response in MS Word format to gornbein@g.ucla.edu

 

      Assignment 1    due 9 Sept, 2024    Peters article     Staudmauer article

 

      Assignment 2    due 23 Sept, 2024

 

      Assignment 3    due 14 Oct, 2024          Julian article

 

      Assignment 4    due 28 Oct, 2024    

                       sample size/power table for comparing two means

                       sample size/power table for comparing two proportions

 

      Assignment 5    due 11 Nov, 2024      Atkins vs Zone article

 

      Assignment 6    optional  Testosterone article

 

    Final presentation instructions

 

      Other papers:  Stratton & Neil -how to ensure paper is rejected

                                   Ioannidis – why published results can be false                   

 

                  Extra problem sets (practice)

 

      Online calculators

         Normal distribution applet / calculator

 

        Power for Comparing two means (comparing mean difference to zero)

 

     Download for free Gpower sample size/power software – University of Dusseldorf (must download and install)

https://www.psychologie.hhu.de/arbeitsgruppen/allgemeine-psychologie-und-arbeitspsychologie/gpower.html

 

          Notes for JMP sessions

        Introduction to JMP – SAS Inc-video

 

      Lab 1 – introduction to JMP(JG)            data for BMI example    depression data (JMP format)

 

         Excel demos and model calculators

              Normal distribution area calculator

              Chi square area (p value) calculator

              F distribution calculator

              Poisson distribution calculator

              t test for means and Z test for proportions-calculator

              power calculation demo – t test

              sample size calculation for comparing two means– t test

              making a chart demo

              proportion comparison Z test calculator

              chi-square test calculation demo

              Logistic regression – diabetes complication risk calculator

               Cox model survival calculator

 

  Datasets in EXCEL (some in JMP) – used to illustrate some material:

       Birth weight (BWEIGHT)         data dictionary for BWEIGHT

       Fat

       PSA

       Svol (semen volume – used in regression)

       Clond BP data                  

       Clond TBI data (used in ANOVA)

       PCO data in JMP format – used for regression

       Depression (CESD) data in JMP format-used for regression

               Depression data dictionary

       Chung-Prati cancer survival data in JMP format

 

     Links to Recorded Lectures (Zoom) – there is a lag before recorded lectures are posted

     Click on link

 

  27 Aug 2024 – Introduction, confounding

  

    3 Sept, 2024 – Bias, Study Design